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Rodent motor units, muscle fibers, and motor proteins undergo significant aging-related changes. Such changes include spatial organization and physiological properties of fast- and slow-twitch single motor units, regulation of contractile speed and force generation capacity at the muscle fiber level, and altered functional properties of the motor protein(More)
The rat is the most extensively characterized species with regard to the regulation of muscle contraction and myofibrillar protein isoform expression, but there is reason to question whether results from small mammals, such as the rat, can be extrapolated directly to larger mammals, such as man. Studies of human muscle contraction have primarily used(More)
The overall architecture of a software system has long been recognized as an important contributor to its quality (or lack thereof). A well-structured program not only adheres to guidelines of structured programming, but also exhibits a logical and modular architecture. Modularity was identified as an important characteristic of software systems by(More)
The rev-erbAalpha orphan protein belongs to the steroid nuclear receptor superfamily. No ligand has been identified for this protein, and little is known of its function in development or physiology. In this study, we focus on 1) the distribution of the rev-erbAalpha protein in adult fast- and slow-twitch skeletal muscles and muscle fibers and 2) how the(More)
Pircher, P., P. Chomez, F. Yu, B. Vennström, and L. Larsson. Aberrant expression of myosin isoforms in skeletal muscles from mice lacking the rev-erbA orphan receptor gene. Am J Physiol Regul Integr Comp Physiol 288: R482–R490, 2005. First published September 16, 2004; doi:10.1152/ajpregu.00690.2003.—The rev-erbA orphan protein belongs to the steroid(More)
Autologous peripheral blood stem cell transplantation (APSCT) is increasingly used in the treatment of breast cancer. We report a patient who experienced septic shock, and after treatment with antibiotics, high-dose corticosteroids and mechanical ventilation due to respiratory insufficiency, developed quadriplegia. Electroneurophysiological examination, as(More)
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