P. Penchala Prasad

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OBJECTIVE Valsartan is an oral antagonist of angiotensin II that competes with angiotensin II for the AT1-receptor and is being developed as an antihypertensive agent. This study assessed the ability of 80 mg valsartan to inhibit the pressor effect of exogenous angiotensin II in healthy normotensive men, first after a single dose and then after multiple(More)
The influence of dietary protein deficiency on the pharmacokinetics and pharmacodynamics of pentobarbital was investigated in male Sprague-Dawley rats fed for 4 weeks on a 23% (control) or 5% (low) protein diet ad libitum. Following a single iv dose of 40 mg/kg sodium pentobarbital, the average mean residence time (MRT) was prolonged by 144% (2.3 +/- 0.2 to(More)
The effects of acute (96 h) water deprivation on the disposition kinetics of antipyrine and hepatic cytochrome P-450 content were investigated in male rats. The disposition kinetics of antipyrine in rats deprived of water for 96 h was altered significantly: the total body clearance and steady-state volume of distribution decreased by 27.1 and 22.4%,(More)
The influence of dietary protein deficiency on the disposition of procainamide (PA) and its major metabolite, N-acetylprocainamide (NAPA) was investigated in male Sprague-Dawley rats fed for 4 weeks on a 23 (control) or a 5% (low) protein diet ad libitum. Procainamide and N-acetylprocainamide in plasma and urine were determined by a sensitive and specific(More)
In the Proposed model, a communication system which converts signal languages, used by dumb people, Quadriplegia and paraplegia are disabilities that result from injuries to the spinal cord and neuromuscular disorders into speech. It is done based on a narrative hand gesture recognition technique. The solution approach consists of a hardware module and(More)
The effect of acute water deprivation for 96 h on renal function was studied in male Sprague-Dawley rats. The glomerular filtration rate (GFR) and the effective renal plasma flow (ERPF) were estimated using inulin and p-amino hippuric acid (PAH), respectively, as model compounds. Acute water deprivation caused a significant decrease (44 per cent) in the GFR(More)
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