P P De Raadt

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A double-centrifugation technique for the detection of trypanosomes in samples of cerebrospinal fluid is described and evaluated. The results of the analysis of samples of cerebrospinal fluid from 128 patients with Trypanosoma brucei gambiense sleeping sickness from the Daloa area of Côte d'Ivoire, obtained using single centrifugation, are compared with(More)
The distribution and epidemiology of parasitic diseases in both urban and periurban areas of endemic countries have been changing as development progresses. The following different scenarios involving Chagas disease, lymphatic filariasis, leishmaniasis and schistosomiasis are discussed: (1) infected persons entering nonendemic urban areas without vectors;(More)
alpha-Difluoromethylornithine (DFMO; eflornithine), an inhibitor of polyamine biosynthesis, was used to treat 14 patients with late stage gambiense sleeping sickness, 12 cases having been previously treated with and considered refractory to melarsoprol. alpha-Difluoromethylornithine was administered intravenously at a dose of 400 mg/kg/day for 14 days(More)
The great sleeping sickness epidemic that occurred in Busoga at the turn of the century was caused by a trypanosome identified by Bruce as Trypanosoma gambiense. A study of trypanosomes from the recent epidemic in southeast Uganda has shed new light on the origins of the disease in Busoga. Thorsten Koerner, Peter de Raadt and Ian Maudlin suggest that the(More)
The Testryp CATT was performed on dried blood samples on filter-paper and on diluted blood using a microtechnique. This method was applied to both sample collection techniques and was evaluated in parallel with the classical Testryp CATT on whole blood, as described in the instructions provided with the reagents by the manufacturer. A total of 2087 people(More)
One serological and six parasitological techniques for diagnosing human trypanosomiasis were compared with regard to sensitivity, specificity, positive and negative predictive values, and practicality in field application in the Luangwa Valley of Zambia. Seven (0.64%) trypanosomiasis cases were diagnosed parasitologically in a survey of 1093 people from 19(More)