P. N. Jayakumar

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OBJECTIVE This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia. METHOD Nineteen schizophrenia patients and 31 age- and sex-matched healthy comparison subjects underwent (31)P MRS. RESULTS The phosphocreatine/total phosphorus and(More)
BACKGROUND Corpus Callosum (CC) abnormalities have been described in schizophrenia. Review of CC measurement methods in schizophrenia reveals inconsistency and lack of neuroanatomical basis. AIMS The aims of the study are to describe a new CC measurement method with valid a neuroanatomical and cytoarchitectural basis and to demonstrate inter-rater(More)
OBJECTIVE To examine the volumetric and metabolic correlates of caudate nucleus in antipsychotic-naïve schizophrenia patients in comparison with healthy controls. METHOD Twelve antipsychotic-naïve schizophrenia patients and 13 healthy controls underwent (31)P magnetic resonance spectroscopy of basal ganglia. Magnetic resonance imaging volume of caudate(More)
OBJECTIVE Studies of Neurological Soft Signs (NSS) in schizophrenia are confounded by handedness, inconsistent methodology, and prior treatment with neuroleptics. The study objective is to examine NSS in never-treated schizophrenia. METHOD We examined the NSS in treatment-naïve schizophrenia patients (n = 21) and age, sex, education, and handedness(More)
OBJECTIVE Constitute hypothesis for origin of supernumerary phantom limb (SPL) after stroke. METHOD Single case description, review of literature and formulation of hypothesis. RESULTS A 59-year-old lady was evaluated for complaints of left-sided hemiparesis and extra limbs attached to her left shoulder for the past 7 months. Neuropsychological(More)
BACKGROUND Although electroconvulsive therapy (ECT) causes no structural brain damage, recent studies reported altered brain perfusion acutely following ECT. This is in keeping with brain edema which was noted in animal experiments following electroconvulsive shock. AIM This study examined alteration in magnetic resonance imaging (MRI) T(2) relaxation(More)
BACKGROUND Evidence suggests that caudate nucleus abnormalities have a role in schizophrenia. Structural brain imaging studies on caudate size in schizophrenia are inconclusive due to confounding factors. METHODS In this study, caudate volume was measured on coronal Magnetic Resonance Images (I -mm) in consenting 15 never-treated schizophrenia (DSM-IV)(More)
Background: Preliminary evidence suggests abnormal basal ganglia and cerebellar loops in schizophrenia. Few studies have examined the striatocerebellar system in never-treated schizophrenia. Objective: The study objective was to examine the striato-cerebellar system using Magnetic Resonance Imaging (MRI) in never-treated schizophrenia. Methods: MRI was done(More)
The aim of the study was to detect brain oedema with electroconvulsive therapy (ECT). Magnetic resonance imaging (MRI) T(2) relaxation time which is an indicator of brain water was measured one day prior to the first ECT and at two hours after second ECT in five depressive patients prescribed right unilateral (RUL) ECT. MRI T(2), relaxation time was(More)
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