P. N. Aleksandrov

Learn More
It was shown in experiments on rats that intraabdominal administration of silver nitrate solution induces peritonitis and the subplantar administration of histamine, serotonin and prostaglandin E2 leads to an acute paw edema. Preliminary subcutaneous administration of esculamine or rutin inhibited the development of the inflammation. Esculamine proved more(More)
Single application of glycine in a final dose of 40 mg/kg to the surface of the parietal area of rat brain produced a potent vasodilatory effect. The diameter of arterioles increased to 250% from the baseline level 1–3 min after treatment. These changes persisted for 5–10 min. In the follow-up period the diameter of vessels progressively decreased to the(More)
Department of Chemotherapy (Chief, Professor A. M. Chernukh), Institute of Pharmacology and Chemotherapy (Director, Acting Member of the Academy of Medical Sciences USSR, Professor V. V. Zakusov), Academy of Medica l Sciences USSR, Moscow (Desented by Acting Member of the Academy of Medical Sciences USSR, V. V. Zakusov) Translated from Byuileten'(More)
Intravital studies of microcirculation and packed-cell volume in microvessels of rat mesentery demonstrated changes in the direction of the flow and packed-cell volume in the course of 17 minutes' ischemia caused by the occlusion of the afferent arteriole. Deficient inflow to the ischemized region is at first compensated for by the inflow from other(More)
Among drugs with vitamin P activity there are some with a marked anti-inflammatory action [7]. One of the important criteria of a promising anti-inflammatory agent is that it should inhibit the development of carrageenan-induced inflammation. It was shown previously [5, 6] that a substance with vitamin P activity, namely the water-soluble hydrochloride of(More)
Rats with experimental pancreatitis manifest a lowering of the serotonin content in mast cells of the mesentery and connective tissue. Injection of prostaglandin E2 first causes a diminution and then an increase in the serotonin content of mast cells. Prostaglandin F2 alpha produces a lowering of the serotonin content of mast cells.
Microvessels of the rabbit ear chamber and blood samples drawn from the internal ear vein were studied after 30-min ischemia. Total microvascular bed area augmented by 16%, total microvascular bed length increased by 9% and mean microvascular diameter increased by 6.7%. One hour after the onset of ischemia it is only the diameter that remains augmented. In(More)
The experiments on rats have shown that intraperitoneal administration of silver nitrate solution induces peritonitis while subplantar histamine, serotonin and prostaglandin E2 administration leads to an acute paw edema. Preliminary subcutaneous injection of lithium hydroxybutyrate prevents the development of inflammation.
A local ultraviolet burn causes inflammation of the mucous membrane of the retrobuccal pouch of the hamster. Substances with D-antiserotonin activity, if applied to the mucous membrane before exposure to UV light, prevent the inflammatory changes. Antihistamine substances do not affect its development.