P. Morley

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Pituitary adenylate cyclase activating peptide (PACAP) is a peptide that is present in the hypothalamus and other areas of the rat brain. This study demonstrates that PACAP reduces food intake after intracerebroventricular injection in food-deprived mice. Behavioral analysis suggests that this decrease in food intake is, in part, compensated for by an(More)
SAMP8 (P8) mice are characterized by impaired learning and memory relatively early in their life, while CD-1 mice show impairment later in life. A series of paternal backcross strains were developed from a CD-1 dame and P8 sire. Siblings from each backcross were bred to establish strains with 50% to 97% P8 genes. F4 mice, 4 or 12 mo of age, were trained to(More)
Fluid ingestion was studied in Fischer 344/Brown Norway F1 rats aged 3, 12, 20, and 24 months of age. There was an age-related decrease in fluid ingestion when fluid intake was measured over 24 h. After water deprivation, 24- and 20-month-old rats drank less than 3- and 12-month-old rats. Twelve, 20-, and 24-month-old rats had less fluid intake associated(More)
A new adaptive patient-controlled analgesia (PCA) system designed to improve PCA through the use of a variable bolus dose and a variable background infusion is outlined here. The handset allows patients to rate their pain on a scale of 1-10. Data derived from the handset signals are used by an expert algorithm to repeatedly adapt the drug dosage of the(More)
Amylin is a pancreatic peptide hormone that has been demonstrated to antagonize a number of the effects of insulin. This study demonstrated that amylin, when administered IP, decreased food intake in 4-month-old rats at doses of 50, 75, and 100 micrograms/kg. Amylin was slightly more potent at suppressing food intake at 13 months of age and less potent at(More)
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