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The effect of a single, oral bedtime dose of the benzodiazepine hypnotics flunitrazepam (FR; 2 mg), flurazepam (FR; 30 mg), and triazolam (TR; 0.5 mg) on the sleep stages and the sleep EEG was investigated in eight healthy, young subjects. In comparison to the placebo night, all drugs reduced the percentage of stage 1 and REM sleep, increased stage 2, and(More)
All-night spectral analysis of the sleep EEG was used to study the effect and after-effect of a single bedtime dose of flunitrazepam (2 mg), flurazepam (30 mg) or triazolam (0.5 mg) in healthy young males. In the night of drug treatment all 3 hypnotics reduced the EEG slow waves and enhanced the activity in the frequency range of sleep spindles. In the(More)
The hypnotic action and residual effects of a single bedtime dose of 8-chloro-6(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine (midazolam, Ro 21-3981, Dormicum) (7.5 or 15 mg) or 8-chloro-6(o-chlorophenyl)-1-methyl-4H-S-triazolo[4,3-a] [1,4]benzodiazepine (triazolam) (0.25 or 0.5 mg) were investigated in young, healthy adults. Motor activity(More)
The benzodiazepine hypnotics triazolam (T) (0.25, 0.5 and 1.0 mg), nitrazepam (N) (10 mg) and flunitrazepam (F) (2.0 mg) were investigated with respect to night-time effects and day-time residual effects, in healthy, young subjects. Drug or placebo was taken orally at home before bed-time. Tests for residual drug effects were administered in the laboratory(More)
The hypnotic action and residual effects of a single bedtime dose of 7-chloro-3-hydroxy-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2(3H)one (temazepam, Planum) were investigated in young, healthy adults. Two different doses of the drug (20 or 30 mg) or placebo were administered as soft-gelatin capsules 30 min before bedtime. Motor activity was recorded by a(More)
A method is described for long-term recording of motor activity with a wrist-worn solid-state activity monitor. Movement-induced signals are integrated over predetermined periods (usually 7.5 min) and stored in the memory (1024 8-bit words) of the device. At 5-day intervals the data are transferred into a minicomputer and plotted in graph form. The(More)
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