Diazepam in vitro produced a concentration-dependent increase of membrane fluidity in crude synaptic membranes from rat hippocampus, but not cerebellum. Similar effects were obtained with higher concentrations of Ro 15-1788 and PK 11195, while zopiclone was completely inactive. In vivo acute treatment with diazepam and Ro 15-1788 gave results similar to… (More)
The effects of low doses of thyrotropin-releasing hormone (TRH, 50 and 200 micrograms) on thyrotropin (TSH) and prolactin levels have been studied in depressed women and compared with the depressive condition and with the results of the dexamethasone suppression test (DST). TRH administration elicited blunted hormonal responses that were not correlated… (More)
Modulation mechanisms of nociception have several neurotransmission interactions that are impaired in the disorder of painful perceptions. Neurotransmission changes may show up in several ways on the clinical level. They also have endocrinological correlations, since the neurotransmission systems implicated in the nociception disorders share transmitters… (More)
Prolactin has been taken as an index of neuroendocrine function in aging, where dopaminergic neurotransmission in considered to be impared. The mean concentration of the hormone in the 24 h is higher in the aged men than in the adult controls. A sleep entrained periodicity is present in both aged subjects and controls, but a harmonic analysis of rhythmicity… (More)
Barbiturate administration (100 mg% m2 body surface) decreases PRL levels in serum during night surge. Daytime levels are not changed. No significant EEG and sleep pattern differences have been observed.
In the course of a clinical trial with 2alpha-bromoergocryptin in Parkinson's disease, the serum levels of several pituitary hormones have been studied in the assumption that the drug active on nigro-striatal dopaminergic system might also interfere with hypothalamus-protuberantial neurotransmission, and have effects on the function of the pituitary. No… (More)