P. Martigne

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The focus of the study is an intercomparison of laboratories' dose-assessment performances using the cytokinesis-block micronucleus (CBMN) assay as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibration data (0.25-5 Gy) as well as blind samples (0.1-6.4 Gy)(More)
In case of a mass casualty radiation event, there is a need to distinguish total-body irradiation (TBI) and partial-body irradiation (PBI) to concentrate overwhelmed medical resources to the individuals that would develop an acute radiation syndrome (ARS) and need hematologic support (i.e., mostly TBI victims). To improve the identification and medical care(More)
Rapid biodosimetry tools are required to assist with triage in the case of a large-scale radiation incident. Here, we aimed to determine the dose-assessment accuracy of the well-established dicentric chromosome assay (DCA) and cytokinesis-block micronucleus assay (CBMN) in comparison to the emerging γ-H2AX foci and gene expression assays for triage mode(More)
The study design and obtained results represent an intercomparison of various laboratories performing dose assessment using the dicentric chromosome analysis (DCA) as a diagnostic triage tool for individual radiation dose assessment. Homogenously X-irradiated (240 kVp, 1 Gy/min) blood samples for establishing calibration data (0.25-5 Gy) as well as blind(More)
This contribution presents and discusses the system concept approach which has been proposed by the European Integrated Project IST-E2R II in the IEEE P1900.B Standardization Study Group (SG); it currently is under further elaboration in the framework of the follow-up IEEE P1900.4 Working Group (WG) whose Project Authorization Request (PAR) was accepted in(More)
An important emerging capability is for mobile terminals to be dynamically reconfigured. Through ongoing advances in technology such as software defined radio, reconfiguration of mobile terminals will in the near future be achievable across all layers of the protocol stack. However, along with the capability for such wide-ranging reconfiguration comes the(More)
Accidents involving human exposure to radiation can cause severe health effects which may require extensive medical resources. Particularly in mass-casualty events, the rapid identification and classification of potentially overexposed individuals into medical treatment groups is of prime importance. For this purpose, clinical signs and symptoms and(More)
The utility of early-phase (≤5 days) radiation-induced clinical signs and symptoms (e.g., vomiting, diarrhea, erythema and changes in blood cell counts) was examined for the prediction of later occurring acute radiation syndrome (ARS) severity and the development of medical management strategies. Medical treatment protocols for radiation accident victims(More)
The evolution of organ damage following extensive high-dose irradiation remains largely unexplored and needs further investigation. Wistar rats [with or without partial bone marrow protection (∼20%)] were irradiated at lethal gamma-ray doses (12, 14, and 16 Gy) and received antibiotic support. While total-body-irradiated rats did not survive, bone marrow(More)