Learn More
Quantitation of near infrared spectroscopic data in a scattering medium such as tissue requires knowledge of the optical pathlength in the medium. This can now be estimated directly from the time of flight of picosecond length light pulses. Monte Carlo modelling of light pulses in tissue has shown that the mean value of the time dispersed light pulse(More)
We have determined the spectral dependence of the temporal point spread functions of human tissues experimentally between 740 and 840 nm in transmittance measurements on the adult head, forearm, and calf (in vivo) and the infant head (post mortem) by using picosecond laser pulses and a streak camera detector. Two parameters are extracted from the temporal(More)
The time taken for an extremely short pulse of near-infrared laser light to traverse the heads of 6 preterm infants was measured after death. The values obtained were used to calculate a differential path length factor (DPF), defined as the mean distance travelled by the photons divided by the distance between the points where light entered and left the(More)
In order to quantify near-infrared spectroscopic (NIRS) data on an inhomogeneous medium, knowledge of the contribution of the various parts of the medium to the total NIRS signal is required. This is particularly true in the monitoring of cerebral oxygenation by NIRS, where the contribution of the overlying tissues must be known. The concept of the time(More)
BACKGROUND Platelet-derived microparticles (PMPs) are generally considered a marker of platelet activation in cardiovascular disease. We studied the extent to which PMP subpopulations parallel platelet activation in vitro and in vivo. METHODS Using flow cytometry, we analyzed PMP subpopulations from resting and activated platelets in vitro (n = 6) as well(More)
A method for finding the singular system of the Mie scattering kernel for continuous data over all angles is given, based on a result for the spherical harmonic expansion of the kernel. This technique provides a limit to the system obtained using discrete data. Results are given for continuous data and finite support. A comparison is made with the(More)
OBJECTIVE To determine the long-term prognostic value of stress imaging and clinical risk scoring for cardiovascular mortality in chest pain patients after ruling out acute coronary syndrome (ACS). METHODS A standard rule-out protocol was performed in emergency room patients with a normal or non-diagnostic admission electrocardiogram (ECG) within 6 h of(More)
BACKGROUND Limited studies report on the additional prognostic value of coronary computed tomography angiography (CCTA) and the coronary artery calcium score (CACS). METHODS For a median of 637 days, 1551 outpatients with chest pain, without known coronary artery disease (CAD) and low or intermediate pre-test probability of CAD, were followed for major(More)