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Prime-boost vaccination strategies against HIV-1 often include multiple variants for a given immunogen for better coverage of the extensive viral diversity. To study the immunologic effects of this approach, we characterized breadth, phenotype, function, and specificity of Gag-specific T cells induced by a DNA-prime modified vaccinia virus Ankara(More)
Priming with a “simplified regimen” of HIV-1 DNA vaccine is as good as a “standard regimen” when boosted with heterologous HIV-1 MVA vaccine P Munseri, A Kroidl, C Nilsson, C Moshiro, S Aboud, A Joachim, C Geldmacher, E Aris, D Buma, E Lyamuya, F Gotch, K Godoy-Ramirez, K Pallangyo, L Maboko, M Marovich, M Robb, M Hoelscher, M Janabi, P Mann, S Joseph, S(More)
Background Vaccinia immunizations have caused peri-/myocarditis. As a result, volunteers receiving Modified Vaccinia Ankara (MVA) are monitored with ECGs. Early Repolarization Syndrome(ERS) has been reported in 1-2% and Left Ventricular Hypertrophy(LVH) in <10% of young, healthy populations across different ethnicities. These changes have been described as(More)
Breadth, phenotype and functionality of Gag-specific T cell responses induced by a heterologous DNA/MVA prime-boost HIV-1 vaccine regimen L Podola, A Bauer, A Haule, L Sudi, C Nilsson, K Godoy-Ramirez, P Mann, M Missanga, B Kaluwa, L Maboko, C Lueer, M Mwakatima, S Aboud, M Bakari, J Currier, M Robb, S McCormack, S Joseph, E Lyamuya, M Hoelscher, B Wahren,(More)
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