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The investigation of neurophysiological mechanisms underlying the functional specificity of brain regions requires the development of technologies that are well adjusted to in vivo studies in small animals. An exciting challenge remains the combination of brain imaging and behavioural studies, which associates molecular processes of neuronal communications(More)
The aim of this study was to demonstrate the potential of a wireless pixelated β+-sensitive intracerebral probe (PIXSIC) for in vivo positron emission tomographic (PET) radiopharmacology in awake and freely moving rodents. The binding of [11C]raclopride to D2 dopamine receptors was measured in anesthetized and awake rats following injection of the(More)
The aim of this study was to demonstrate the ability of a recently developed β+-range sensitive intracerebral probe (β-Microprobe) to measure the binding kinetics of [18F]MPPF, a well-documented 5-HT1A serotoninergic receptor ligand, in the dorsal raphe nucleus (DRN) of the anaesthetised rat. This midbrain nucleus presents a high concentration of 5-HT1A(More)
UNLABELLED The evaluation of every new radiotracer involves pharmacokinetic studies on small animals to determine its biodistribution and local kinetics. To extract relevant biochemical information, time-activity curves for the regions of interest are mathematically modeled on the basis of compartmental models that require knowledge of the time course of(More)
Tyrosine hydroxylase (TH) catalyzes the first and rate-limiting step in the biosynthesis of catecholamines. Among the various mechanisms implicated in the regulation of TH activity, alternative splicing of TH primary transcript has been described as a characteristic of higher primates and Drosophila. We investigated whether there is such a regulatory(More)
In this paper, the authors validated the microPET FOCUS modelling with GATE. The performances of this Monte Carlo platform were presented on voxelized rat brain phantom, specially for the simulation of realistic [C-11]Raclopride exam with a realistic modelling of the injected dose and acquisition time. These results are the consequence of complete(More)
The aim of this work was to demonstrate the pharmacokinetic potential of a wireless pixelated β+-sensitive probe (PIXSIC). The binding of 2′-methoxyphenyl-(N-2′-pyridinyl)-p-[18F]fluoro-benzamidoethylpiperazine ([18F]MPPF), a 5-HT1A serotonin receptor radiopharmaceutical, was measured in anesthetized rats and compared to microPET data. The effects of a(More)
UNLABELLED As mouse imaging has become more challenging in preclinical research, efforts have been made to develop dedicated PET systems. Although these systems are currently used for the study of physiopathologic murine models, they present some drawbacks for brain studies, including a low temporal resolution that limits the pharmacokinetic study of(More)
We present a design study of PIXSIC, a new &#x03B2;<sup>+</sup> radiosensitive microprobe implantable in rodent brain dedicated to in vivo and autonomous measurements of local time activity curves of beta radiotracers in a small (a few mm<sup>3</sup>) volume of brain tissue. This project follows the initial &#x03B2; microprobe previously developed at IMNC,(More)
Elucidating complex physiological mechanisms in small animal in vivo requires the development of new investigatory techniques including imaging with multiple modalities. Combining exploratory techniques has the tremendous advantage to record simultaneously complementary parameters on the same animal. In this field, an exciting challenge remains in the(More)