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Interactions between neurons and astrocytes play a critical role in the central nervous system homeostasis. Cyperus rotundus (family: Cyperaceae), a traditional Indian medicinal herb, used as nervine tonic and nootropic in the Ayurvedic system of medicine. The present study was undertaken to investigate the neuroprotective effect of total oligomeric(More)
Telmisartan (TEL), an angiotensin type 1 receptor (AT1R) antagonist, has been reported to exert neuroprotective effect in animal models of Parkinson's disease (PD). However, its effect on motor functions, mutant protein α-synuclein (SYN) and neurotrophic factors (BDNF and GDNF) expression and their interrelation in PD has not yet been elucidated. In the(More)
Software testing is a prime factor in software industry. Besides knowing the importance of testing, only limited time is allocated for teaching it. It will be more efficient if testing is taught simultaneously with programming foundations. This integrated learning of testing techniques and programming allows the programmers to perform in a better way and(More)
Transplants, besides providing neural replacement, also stimulate host regeneration, which could serve as a powerful means to establish functional recovery in CNS insults. Earlier, we have reported the H3-GFP transplant mediated recovery of cognitive functions in the ventral subicular lesioned rats. In the present study, we demonstrate the efficacy of a(More)
The information retrieval systems that are present nowadays are mainly based on full text matching of keywords or topic based classification. This matching of keywords often returns a large number of irrelevant information and this does not meet the user's query requirement. In order to solve this problem and to enhance the search using semantic(More)
Large volumes of data are available in the web. The discussion forum, review sites, blogs and news corpora are some of the opinion rich resources. The opinions obtained from those can be classified and used for gathering online customer's preferences. Techniques are being applied to design a system that identifies and classify opinions spread largely in the(More)
Memantine (MN), a NMDA blocker is well known for its protective effect against various neurodegenerative diseases. However, its role in improving motor function and regulation of neurotrophic factors in Huntington's disease (HD) has not been studied yet. In the present study, we have investigated the effect of MN against 3-nitropropionic acid (3NP), induced(More)
In the present study, the efficacy of citicoline in alleviating the ischemia/reperfusion neuronal injury was investigated in male Sprague Dawley rats. Citicoline was administered before inducing ischemia, during ischemia and after reperfusion. Animals were scored for neurological deficits, assessed for anxiety, cognition and motor activity. Sodium potassium(More)
PURPOSE OF RESEARCH Since, transient focal cerebral ischaemia exhibits detrimental effect not only during the course of ischaemia but also after the onset of reperfusion, the current study is focussed on identifying the appropriate therapeutic time point at which NG-nitro-l-arginine methyl ester (l-NAME) exerts better neuroprotection. PRINCIPAL RESULTS(More)
Use of antiepileptic drugs (AEDs) in pregnancy warrants various side effects and also deleterious effects on fetal development. The present study was carried out to assess the effects of prenatal exposure to lamotrigine (LTG) on postnatal development and behavioural alterations of offspring. Adult male and female Sprague Dawley rats weighing 150-180 g b.(More)