P Jouan

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In anterior pituitaries from male rats, it appeared that 5 alpha-androstane-3 beta,17 beta-diol was quickly metabolized into 5 alpha-androstane-3 beta,6 alpha-17 beta-triol and 5 alpha-androstane-3 beta,7 alpha,17 beta-triol by action of 6 alpha- and 7 alpha-hydroxylases. Hydroxysteroid hydroxylases were located in endoplasmic reticulum and were dependent(More)
In the male rat pituitary, 5alpha-androstane-3beta, 17beta-diol (3beta-diol) is extensively metabolized into polar steroids. They were identified as 5alpha-androstane-3beta, 6alpha-17beta-triol (6alpha-triol) and 5alpha-androstane-3beta, 7alpha, 17beta-triol (7alpha-triol). 6-alpha-Triol represents 53% and 7alpha-Triol 28% of the total 3beta-diol(More)
The in vivo and in vitro metabolism of (3H)-5alpha-androstane-3lapha,17beta-diol by the male rat anterior pituitary was studied. A rapid and intensive conversion of 5alpha-androstane-3alpha, 17beta-diol into 5alpha-dihydrotestosterone was demonstrated, since following a 30 min. incubation time, 73% of the recovered radioactivity were constituted by(More)
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