P J McElroy

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This report describes studies designed to assess the immunomodulatory effects associated with the consumption of coho salmon containing halogenated aromatic hydrocarbons (HAHs) and other compounds naturally bioaccumulated from Lake Ontario. Diets containing 33% coho salmon from Lake Ontario or the Pacific Ocean were fed to juvenile C57Bl/6 mice for 2-4 mo.(More)
Exposure of 2,4-dinitrophenyl (DNP)-hemocyanin-primed spleen cells to DNP-conjugated pneumococcal polysaccharide (DNP-S3) in vivo or in vitro renders such cells unresponsive to DNP-hemocyanin challenge following adoptive transfer. The unresponsiveness is hapten-specific, independent of the presence of T cells and adherent cells, and not due to either toxic(More)
We describe the immune status of a congenitally asplenic, otherwise healthy and anatomically normal 30-year-old woman. As in surgically asplenic subjects, she had Howell-Jolly bodies in a blood smear, increased B lymphocyte and decreased T helper and suppressor lymphocyte percentages, and a slightly lower than average T helper/suppressor ratio. Because of(More)
Rabbit pre-B cells are almost uniformly large and low in density and bear a modest number of Fc receptors (McElroy, P.J., Willcox, N. and Catty, D., Eur. J. Immunol. 1981. 11:76). A simple density gradient centrifugation procedure consistently and rapidly enriches them to 20-35% frequencies. At the same time, it depletes them of most of the B cells,(More)
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