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  • Anne M. Krantz, Leslie J. Copp, P J Coles, Richard A. Smith, Stephen B. Heard
  • Chemistry, Medicine
  • Biochemistry
  • 1991 (First Published: 1 May 1991)
  • (Acyloxy)methyl ketones, of general structure Z-[AA2]-[AA1]-CH2OCOAr, are potent inactivators of the cysteine proteinase cathepsin B. These reagents have been designed as affinity labels in which theContinue Reading
  • Diana Helen Pliura, B J Bonaventura, Richard A. Smith, P J Coles, Anne M. Krantz
  • Chemistry, Medicine
  • The Biochemical journal
  • 1992 (First Published: 15 December 1992)
  • Peptidyl acyloxymethyl ketones, previously established as potent inactivators of the lysosomal cysteine proteinase cathepsin B, were evaluated against smooth-muscle calpain, a member of the family ofContinue Reading
  • Richard A. Smith, P J Coles, Robin W. Spencer, Leslie J. Copp, Christopher Stephen Jones, Anne M. Krantz
  • Chemistry, Medicine
  • Biochemical and biophysical research…
  • 1988 (First Published: 1 September 1988)
  • Peptidyl O-acyl hydroxamates having appropriate active-site recognition features are very potent time-dependent inhibitors of the cysteine proteinase cathepsin B. The inhibition is irreversible, andContinue Reading
    The Hayward Gallery's British Art Show, mounted every five years, celebrates the vitality and inventiveness of contemporary British art. "British Art Show 5 "showcases work by a cross-generationalContinue Reading