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The effects of aged garlic extract (AGE) on longevity and learning and memory performances were studied in the senescence accelerated mouse (SAM). A solid diet containing 2% (w/w) AGE was given to SAM from 2 months of age. The survival ratio of SAM P8, senescence accelerated animals, treated with AGE was significantly higher than that of untreated controls.(More)
Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following axotomy was investigated. The axonal(More)
The effect of an herbal prescription, S-113m, consisting of biota, ginseng and schizandra, on learning and memory performance was studied in the senescence accelerated mouse (SAM). A solid diet containing 1% (w/w) S-113m was given to SAM from 1 month of age. A behavioral experiment, started 4 or 9 months later, revealed prominent learning impairment in(More)
The effects of spermine, spermidine and putrescine on the survival and morphology of hippocampal neurons obtained from rat embryos were investigated using low cell density culture. The number of surviving neurons gradually decreased in the control cultures, while addition of spermine significantly promoted neuronal survival. The survival-promoting effect of(More)
We investigated the structure-activity relationship for the neurotrophic activity of spermine by comparing the effects of several synthetic spermine analogues on the survival of cultured rat hippocampal neurons. N,N'-bis(3-aminopropyl)-1,6-hexanediamine and N,N'-bis(3-aminopropyl)-1,3-propanediamine did not promote the neuronal survival, suggesting that the(More)
Axons of cultured rat hippocampal neurons were injured by local irradiation of laser beam, and the effects of spermine, spermidine and putrescine on neurite regeneration following axonal injury were investigated. The axonal growth was stopped by laser irradiation, but addition of spermine remarkably promoted the axonal re-elongation from the injured site.(More)
Small stem cells, such as spore-like cells, blastomere-like stem cells (BLSCs), and very-small embryonic-like stem cells (VSELs) have been described in recent studies, although their multipotency in human tissues has not yet been confirmed. Here, we report the discovery of adult multipotent stem cells derived from human bone marrow, which we call StemBios(More)
We previously found that spermine potently promotes the neuronal survival and regeneration of primary cultured brain neurons. N-(3-Aminopropyl)cyclohexylamine (APCHA) was originally developed as a spermine synthase inhibitor. To test if endogenous spermine biosynthesis contributes to neuronal survival and morphogenesis, we examined the effects of APCHA in(More)
We have previously found that spermine, spermidine and putrescine promote axonal regeneration following axotomy in cultured rat hippocampal neurons. In the present study, we investigated which part of the polyamine molecule is responsible for the regeneration-promoting effect. Testing the effects of several synthetic analogues revealed that the(More)
The facilitating or antagonizing effects of polyamine analogues on N-methyl-DL-aspartate (NMDLA)-induced seizures were investigated using mice. Intracerebroventricular injection of spermidine and spermine, but not putrescine, shortened the latency to appearance of clonic convulsion induced by subcutaneous administration of NMDLA. Injection of(More)