P. Harilal

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Alteration of the tumour-suppressor gene p53 is the commonest genetic change encountered in human malignant tumours. A study was undertaken to ascertain the prognostic value of p53 immunoexpression in nephroblastomas. A series of 93 consecutive cases was analysed. Archival formalin-fixed, paraffin wax-embedded tissue sections were stained with monoclonal(More)
AIMS To investigate the immunohistochemical expression of CD31 (JC70) in normal and neoplastic plasma cells. METHODS Plasma cells in bone marrow biopsies and extramedullary locations were examined. All extramedullary biopsies were formalin fixed and paraffin embedded. The bone marrow biopsies were fixed in formal acetic acid and embedded in paraffin wax.(More)
The level of expression of the cell cycle regulatory proteins is an important facet in determining the malignant state. Fifty consecutive colectomy specimens of colorectal carcinoma in patients over 50 years of age, and 25 cases in patients under 30 years, were examined to ascertain retinoblastoma protein expression and to relate this to clinicopathological(More)
Bcl-2 expression has been shown to relate to prognosis in several neoplasms. A study of 139 cases of nephroblastomas was undertaken to ascertain the prognostic value of bcl-2 immunoexpression. Archival formalin-fixed, paraffin-embedded tissue sections were stained with monoclonal anti-bcl-2 antibody using a peroxidase-labelled streptavidin biotin kit. 75.5%(More)
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