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Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) not closely related to groups outside the subcontinent. The date of mixture is unknown but has implications for understanding Indian(More)
Saccharum spontaneum L., one of the wild species in Saccharum complex has reservoir of genes for various economically important traits including resistance to biotic and abiotic stresses. Its contribution in the development of modern sugarcane varieties through nobilization has resulted in the first sugar revolution in the country. In India, many(More)
The Siddis (Afro-Indians) are a tribal population whose members live in coastal Karnataka, Gujarat, and in some parts of Andhra Pradesh. Historical records indicate that the Portuguese brought the Siddis to India from Africa about 300-500 years ago; however, there is little information about their more precise ancestral origins. Here, we perform a(More)
BACKGROUND Mitochondrial DNA (mtDNA) mutations are known to cause Leber hereditary optic neuropathy (LHON). However, the co-occurrence of double pathogenic mutations with different pathological significance in pedigrees is a rare event. METHODS Detailed clinical investigation and complete mtDNA sequencing analysis was performed for two Indian families(More)
Networks of the future will be characterized by a variety of computational devices that display a level of dynamism not seen in traditional wired networks. Because of the dynamic nature of these networks, resource discovery is one of the fundamental problems that must be faced. While resource discovery systems are not a novel concept, securing these systems(More)
Molecular markers are powerful tools, which help in differentiating plant varieties at the DNA level and have been widely used for genetic diversity studies in a number of crop species'. Understanding the genetic diversity of available clones of S. officinarum and S. spontaneum will be helpful in breeding programs. In the present study, a set of 48(More)
BACKGROUND Constitutional type of an individual or prakriti is the basic clinical denominator in Ayurveda, which defines physical, physiological, and psychological traits of an individual and is the template for individualized diet, lifestyle counseling, and treatment. The large number of phenotype description by prakriti determination is based on the(More)
PURPOSE To investigate the clinical and mitochondrial DNA (mtDNA) haplogroup background of Indian Leber hereditary optic neuropathy (LHON) patients carrying the m.14484T>C mutation. METHODS Detailed clinical investigation and complete mtDNA sequencing analysis was carried out for eight Indian LHON families with the m.14484T>C mutation. Haplogroup was(More)
DNA methylation and its perturbations are an established attribute to a wide spectrum of phenotypic variations and disease conditions. Indian traditional system practices personalized medicine through indigenous concept of distinctly descriptive physiological, psychological and anatomical features known as prakriti. Here we attempted to establish DNA(More)
Chronic progressive external opthalmoplegia (CPEO) is the most common phenotypic syndrome of the mitochondrial myopathies. Muscle biopsy, which provides important morphological clues for the diagnosis of mitochondrial disorders, is normal in approximately 25% of patients with CPEO, thus necessitating molecular genetic analysis for more accurate diagnosis.(More)