P Garcia-Sablone

Learn More
Chromogranins constitute a family of acidic soluble proteins widely distributed in endocrine cells and neurons. Chromogranin A, the major soluble component in bovine adrenal medullary secretory granules in chromaffin cells, has been shown to be actively processed to peptide fragments [Metz-Boutigue, M. H., Garcia-Sablone, P., Hogue-Angeletti, R. & Aunis, D.(More)
Chromogranins are a family of acidic soluble proteins which exhibit widespread distribution in endocrine cells and neurons. Chromogranin A (CGA), the major soluble component of the secretory granules in chromaffin cells of the adrenal medulla, is a single polypeptide chain of 431 residues with an apparent molecular mass of 70-75 kDa and a pI of 4.5-5. In(More)
Chromogranin A (CGA) is a calcium-binding glycoprotein thought to be the precursor of several peptides with defined biological activity. Chromogranin A has been localized in most endocrine cells and many neurons in the CNS. Here we studied its expression in neurons of the hypothalamo-neurohypophysial system, which secrete the neurohormones oxytocin and(More)
  • 1