P. F. Litvitskii

Learn More
The evidence is presented and on development of both adaptive and pathogenic changes in the heart in its regional ischemia followed by renewal of circulation in major branches of coronary arteries. Cellular and molecular mechanisms of cardiac changes are characterized: energy supply to cardiomyocytes; their membrane physico-chemical status and structure,(More)
The widespread occurence of various forms of coronary insufficiency determines the urgency for development of methods of increasing the resistance of the myocardium to oxygen lack. One such method is training by means of hypoxia, during which certain adaptive effects can be achieved, some of them at the heart level. They include an increase in the(More)
The data obtained in experiments on 89 random bred male white rats indicate an important pathogenetic role of lipid peroxidation activation during ischemia of the myocardium and its further reperfusion. Inhibition of lipid peroxidation by sodium selenite was accompanied by increased resistance of the heart to its reversible ischemia. The evidence obtained(More)
Experiments on 98 noninbred white male rats with experimental transitory coronary insufficiency (TCI) have confirmed the essential pathogenetic role of activation of myocardial free-radical lipid peroxidation (FRLP) in the mechanism of its development. Evidence has been also provided for FRLP suppression in the course of preventive use of myophedrine. It(More)
the pa s sage of t ime , however , the ro le of the c o m m i s s u r a l components may be enhanced, and this p robably leads to equalizat ion of the background level of r eac t iv i ty of the pupils . Additional divis ion of the c o m m i s s u r a l pa th ways (cats of group 3) led to s eve re and last ing an i socor ia . The absence of any apprec iable(More)
T. S. Paskhina, V. L. Dotsenko, and E. I. Blinnikova, Biokhimiya, 38, 420 (1973). T. S. Paskhina and V. P. Zykova, Dokl~ Akad. Nauk SSSR, 173, 1451 (1967). T. S. Paskhina and A. V. Krinskaya, Vopr. Med~ Khim., 20, 660 (1974). T. S. Paskhina and G. A. Yarovaya, Biokhimiya, 35, 1055 (1970), D. E. Chambers, Nature, 197, 300 (1963)~ H. Takahashi, S. Nagasawa,(More)
Increased resistance of the heart to acute transitory coronary insufficiency under conditions of prophylactic use of molsidomin was demonstrated in experiments on dogs and rats. The agent prevents electric destabilization of the heart. Reduction of pre- and postexertion of the heart is one of the main factors of the protective action of molsidomin. It is(More)