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Thousands of harbor seals (Phoca vitulina) died in European seas during 1988. Respiratory distress and oculonasal discharge were common clinical signs. We necropsied 76 affected seals. The main necropsy finding was severe pneumonia. Microscopic lung changes were characterized by proliferation of type II pneumocytes, filling of alveolar lumina with(More)
Nine young calves given respiratory syncytial virus by a combined intranasal and intratracheal route developed a severe respiratory tract disease in which coughing, tachypnea, and hyperpnea were prominent clinical features. Calves were euthanatized on postinoculation (initial) days (PID) 1 to 13. At necropsy, large areas of consolidation were present in the(More)
Ultrastructural changes observed in the acute and repair stages of experimental P13 virus pneumonia in young calves are described. In the early acute stage of the pneumonia, paramyxovirus replication was observed within epithelial cells of the respiratory tract and within alveolar macrophages. There was loss of cilia and of ciliated cells in small bronchi(More)
During 1988 thousands of harbor seals (Phoca vitulina) died in European seas as a result of morbillivirus infection. Six harbor porpoises (Phocoena phocoena) found stranded on the coast of Northern Ireland in late 1988 were submitted to our laboratory for necropsy. Pneumonia was the main necropsy finding in three of these animals. Microscopic lung lesions(More)
Using an avidin-biotin-peroxidase complex immunoperoxidase staining method, respiratory syncytial virus (RSV) antigen was demonstrated in glutaraldehyde-fixed, paraffin-processed lung sections from calves with induced RSV pneumonia. The virus also was detected in formalin-fixed, paraffin-processed lung sections from calves with naturally occurring RSV(More)
Thirteen colostrum deprived calves were inoculated with a low passage field strain of parainfluenza type III (PI 3) virus. Virus was administered by the intranasal route and the calves were experimentally infected twice daily for four consecutive days. Clinical signs of respiratory disease were noted and pneumonia was present in 12 animals at necropsy. PI 3(More)