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The aim of the study was to investigate the use of hyperglycaemic clamp tests to identify individuals who will develop diabetes among insulinoma-associated protein-2 antibody (IA-2A)-positive first-degree relatives (IA-2A+ FDRs) of type 1 diabetic patients. Hyperglycaemic clamps were performed in 17 non-diabetic IA-2A+ FDRs aged 14 to 33 years and in 21(More)
We investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high risk of type 1 diabetes. During an initial sampling, random glycaemia, proinsulin, PI:C and HLA DQ genotype were determined in 561 non-diabetic first-degree relatives who had been positive for islet(More)
Insulin resistance has been proposed as a risk factor for type 1 diabetes. We investigated whether adiponectin, an insulin sensitiser, can serve as an additional predictive marker for type 1 diabetes in first-degree relatives of known patients. Adiponectin was followed in 211 persistently islet antibody-positive (Ab+) first-degree relatives of type 1(More)
A built-in I/sub DDQ/ monitor for CMOS digital circuits with low power supply voltage perturbation is presented. It minimizes the extra delay of the CUT in normal operation. An automatic recovery mechanism limits the drop in VDD voltage during the testing phase so the data storage is not perturbed. The I/sub DDQ/ current level may be measured by a standard(More)
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