G. G. Bond1
I. C. Munro1
R. Saracci1
1G. G. Bond
1I. C. Munro
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SEVERAL issues pertinent to the validation of screening tests and to the evaluation of screening programmes have evolved, largely in the epidemiological and general laboratory scientists interested in the development and validation of carcinogen screening tests may not be fully aware of some useful concepts. The paper reviews several such concepts and their(More)
The phenoxy herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) is widely used to control the growth of weeds and broadleaf plants. We convened a panel of 13 scientists to weigh the evidence on the human carcinogenicity of 2,4-D. The panel based its findings on a review of the toxicological and epidemiological literature on 2,4-D and related phenoxy(More)
Human bronchoalveolar macrophages were separated from other free lung cells by density sedimentation on Percoll gradients. They were then tested for cytotoxicity against the human lung adenocarcinoma cell line A549, using a Selenomethionine-75 post-labelling assay. The cytotoxicity of the macrophages increased as the effector:target cell ratio was(More)
Maturation of monocytes into macrophages in vitro has been assayed by a quantitative microtitre assay in patients with squamous-cell carcinoma of the lung. Monocyte maturation in autologous serum was significantly depressed in patients with both limited and extensive disease compared with normal controls, patients with chronic obstructive airways disease(More)
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