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OBJECTIVE Epidemiological studies in the United States consistently find autism spectrum disorders (ASD) to be overrepresented in high socioeconomic status (SES) families. These findings starkly contrast with SES gradients of many health conditions, and may result from SES inequalities in access to services. We hypothesized that prenatal measures of low,(More)
A report was made on the outcome of a four year retrospective study in 27 064 pregnancies, of the clinical efficiency, sensitivity, and specificity of a screening programme for Down's syndrome based on reported strategies related to the measurement of maternal serum alpha fetoprotein. This study identified 27 pregnancies affected by Down's syndrome with a(More)
OBJECTIVE The Computerized Patient Record System is deployed at all 173 Veterans Affairs (VA) medical centers. Providers access clinical notes in the system from a note title menu. Following its implementation at the Nashville VA Medical Center, users expressed dissatisfaction with the time required find notes among hundreds of irregularly structured(More)
John Haslam's description of James Tilly Matthews is the earliest clear description of schizophrenia in British psychiatric writing. Matthew's life and symptomatology are described. The reasons why there are few unambiguous contemporary accounts of schizophrenia are explored. Schizophrenia was probably first described in Britain during the Georgian period(More)
Light therapy is a recognized treatment for sleep phase disorders in the general population. Exposure to natural light can be a powerful means of correcting people's sleep/wake pattern. Although sleep problems in the learning-disabled population are common, research is limited. Light therapy has not to our knowledge been studied in this population. We(More)
OBJECTIVE To assess the value and impact of a screening programme for Down's syndrome that uses the two maternal serum markers: alpha fetoprotein and free beta human chorionic gonadotrophin. DESIGN All women booked into clinics were screened. Further tests were offered to women with a risk of one in 300 or greater of having an affected baby. Follow up of(More)
BACKGROUND Alzheimer's dementia (AD) is the most common form of dementia in people with Down Syndrome [DS]. Acetylcholine is a chemical found in the brain that has an important role in memory, attention, reason and language. Donepezil a reversible inhibitor of acetylcholinesterase, which is thought to maintain levels of acetylcholine, and is reported to(More)
This case report describes a person with Prader-Willi syndrome who recently died, aged 71 years. It is suggested that her longevity was helped by being female, with a moderate degree of mental handicap and a degree of weight control which reduced the problems of diabetes and hypertension.
BACKGROUND Alzheimer's dementia (AD) is the most common form of dementia in people with Down Syndrome (DS). There is an understanding that an increase in L-glutamate contributes to the pathogenesis of cerebral ischemias and AD. Memantine acts as an antagonist of N-methyl-D-aspartate (NMDA) type receptors, which is thought to reduce abnormal activation of(More)