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The role of several activated oxygen species in the oxidation and binding of B[a]P to calf thymus DNA in vitro was investigated. B[a]P was reacted with calf thymus DNA in the presence and absence of scavengers of active oxygen species. Reactions were performed in the dark at 37 degrees C for 30 min in a buffered aqueous solution with 250 micrograms of calf(More)
The binding of benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, 3-methylcholanthrene, benz[a]anthracene, dibenz[a,c]anthracene and phenanthrene to calf thymus DNA in vitro in the absence of enzymatic or chemical activation was investigated using the 32P-postlabeling assay. Reactions were performed in the dark or under white light in 1 ml of Tris-HCl buffer(More)
Studies have demonstrated that the metabolic activation of benzo[j]fluoranthene (B[j]F) to a genotoxic agent proceeds through the formation of either the trans-4,5-dihydrodiol (B[j]F-4,5-diol) or the trans-9,10-dihydrodiol (B[j]F-9,10-diol) metabolite of B[j]F. Using 32P-postlabeling analysis, the profiles of DNA adducts formed in vivo in mouse skin from(More)
Suche zapalenie spojówek i rogówki u zwierząt (KCS) powstaje na skutek zubożonej produkcji łez, co skutkuje ich niedoborem. Choroba objawia się wysuszeniem powierzchni oka. Oko jest zaczerwienione, zwierzę odczuwa świąd. Pojawiają się na powierzchni rogówki keratopatie. Schorzenie występuje u psów, kotów a nawet koni. W miarę trwania choroby, wokół oczu na(More)
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