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MOTIVATION Gene expression is regulated by different kinds of short nucleotide domains. These features can either activate or terminate the transcription process. To predict the signal sites in the 5' and 3' gene regions we applied the Hamming-Clustering network (HC) to the TATA box, to the transcription initiation site and to the poly(A) signal(More)
A filter based on a set of unsupervised neural networks trained with a winner-take-all strategy discloses signals along the coding sequences of G-protein coupled receptors. By comparing with the existing experimental data it appears that these signals correlate with putative functional domains of the proteins. After protein alignment within subfamilies,(More)
Small heat shock proteins (sHSPs) are present in all kingdoms of life and play fundamental roles in cell biology. sHSPs are key components of the cellular protein quality control system, acting as the first line of defense against conditions that affect protein homeostasis and proteome stability, from bacteria to plants to humans. sHSPs have the ability to(More)
The mirna targets detection is a key goal of computational biology. This class of non-coding RNA have acquired appreciable importance in understanding molecular mechanism of diseases. In this paper we have investigated the relations between compositional fetures of microrna precursors and the target recognition of corresponding mature micrornas. In(More)
In the last decade the role played by miRNAs in post-transcriptional gene expression control has acquired great importance for molecular biology. In fact, the analysis of miRNA expression profile could be a powerful support for the identification of new biomarkers of diseases. The availability of miRNA specific microarray has allowed to obtain a `mirnomic'(More)
Mapping of the coding sequences of the best characterized subfamilies of G-protein-coupled receptors is performed with unsupervised neural networks based on a winner-take-all strategy. High order features therefrom extracted originate signals along the aligned protein sequences of the different subfamilies. These plots reveal characteristic domains common(More)
The high frequency dielectric constant of poly-adenine (poly-A) was measured between 1 MHz and 1 GHz. The purpose of these experiments was to investigate the state of water molecules that are bound to the charged groups of the poly-A molecule. Analysis of the data using the Maxwell's mixture equation revealed the dielectric constant of bound water higher(More)
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