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Aneuploidy plays a significant role in adverse human health conditions including birth defects, pregnancy wastage and cancer. Although there is clear evidence of chemically induced aneuploidy in experimental systems, to date there are insufficient data to determine with certainty if chemically induced aneuploidy contributes to human disease. However, since(More)
In its evaluation, the task force examined the significance of aneuploidy in human disease, the methods for detecting aneugens, the mechanisms by which aneugens exert their action and how aneugens, as mutagens, are evaluated by regulatory authorities worldwide. Recommendations for the testing of aneugens and for risk characterisation of chemicals with(More)
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