P A van Dongen

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The motor pattern underlying locomotion in the lamprey can be elicited in the spinal cord in vitro by applying excitatory amino acids that activate NMDA receptors. When this is done oscillatory membrane potentials phase-linked with the locomotory rhythm can be recorded in different types of neurones. In some spinal neurones large amplitude oscillation(More)
Toxocara seroprevalence and the relation between Toxocara seroprevalence and allergic asthma were investigated in Dutch schoolchildren aged 4-6 years. Data on Toxocara antibodies, allergen-specific immunoglobulin E, allergic manifestations, and risk factors (pets and playgrounds) were obtained from 235 children from The Hague and 477 from Rotterdam, the(More)
BACKGROUND Prucalopride (PR) is a novel 5-HT4 agonist enterokinetic compound. AIM To evaluate its effect on bowel function, gut transit and anorectal function in healthy volunteers using a double-blind, placebo-controlled crossover study. METHODS Twenty-four healthy volunteers (12 men, 12 women, mean age 25 years, range 20-53 years) were randomly(More)
The distribution of some putative neurotransmitters was investigated in the spinal cord and spinal ganglia of the lamprey, a primitive vertebrate, by using immunohistochemical methods. In the spinal cord a midline row of 5-hydroxytryptamine (5-HT)-immunoreactive neurons was present immediately ventral to the central canal over the entire length of the(More)
The actions of 5-hydroxytryptamine (5-HT) on single neurons in the lamprey spinal cord have been investigated by intracellular recordings in vitro. Administration of 5-HT either by pressure ejection or by perfusion in the bath caused a reversible reduction of the late phase of the afterhyperpolarization (AHP) following the action potentials. This effect was(More)
We have investigated 234 children (3-6 years of age) in The Hague, The Netherlands, for the presence of antibodies against Toxocara. Of these children 26 (11.1%) were seropositive to Toxocara. Cross-reactions with antibodies against Ascaris could be excluded. Of the seropositive children 31% had asthma or bronchitis, while this percentage was only 12% for(More)
A framework of concepts on structure and function of the nervous system is presented, in which we attempt to formulate the intended meanings of some ambiguous statements on structure and function in neurobiology in a set of strictly defined concepts. Function. The word "function" as generally used has different meanings. Two meanings of the question "What(More)