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Review of studies about HLA antigens and multiple sclerosis (MS). The HLA system, in special class II antigens, subregions DR and DQ, is probably involved in the immunopathogenesis of MS. Haplotype DRB1*1501.DQA1*0102.DQB1*0602, corresponding to phenotype DR2.Dw2.DQ6, is positively associated with MS in several caucasoid populations. Clinical heterogeneity(More)
The authors make a review and critical analysis of twin studies in multiple sclerosis (MS). The concordance rate among homozygotic twins is significantly greater than in heterozygotic twins. The average hertability in MS is about 28%; no single gene was identified as a sole risk factor for the development of the disease. MS may be considered a polygenic(More)
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