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An abnormal hyperechogenecity of substantia nigra is thought to be the most characteristic sonographic feature in Parkinson's disease (PD). However specificity and sensitivity of the ultrasound method should be refined. Using transcranial sonography, authors have examined 168 patients with different clinical signs of parkinsonism, including 99 patients with… (More)
Parkinson's disease is a complex disease characterized by a progressive degeneration of nigrostriatal dopaminergic neurons. Development of this condition is defined by interaction between the genetic constitution of an organism and environmental factors. The analysis of the genes associated with development of monogenic forms of disease, has allowed… (More)
The allele and genotype frequencies of 14 SNPs of renin-angiotensin (REN, AGT, AGTR1, AGTR2, BKR2, and ADRB2) and hemostasis (FGB, F2, F5, F7, ITGB3, SERPINE1, MTHFR) system genes, as well as of the ACE insertion-deletion polymorphism, were analyzed in patients with ischemic stroke and in healthy controls matched by age, sex, and ethnicity. Genotyping was… (More)
Two polymorphisms in the PDE4D gene – SNP41 (rs152312) and SNP87 (rs2910829), encoding phosphodiesterase 4D – were studied in patients during the acute period of stroke (n = 577) and a control cohort (n = 270). Significant differences between these cohorts were found in the distributions of genotype and allele frequencies for the SNP41 polymorphism. The AA… (More)
We describe here our studies of the effects of single doses and courses of the synthetic tuftsin analog Selank (a peptide with the sequence Thr-Lys-Pro-Arg-Pro-Gly-Pro) at a dose of 200 μg/kg on the transcription profile of rat hippocampal cells using a cDNA microarray method. Single doses of Selank produced more than two-fold changes in the mRNA levels of… (More)
Polymorphisms of the genes of the glutamatergic system EAAT2, GRIA1, and GRIA2 have been analyzed in patients with sporadic motor neuron disease (MND) from Russia. The disease is not associated with polymorphic alleles of the genes studied, which indicates that EAAT2, GRIA1, and GRIA2 play an insignificant role in the pathogenesis of sporadic MND.
Semax is a synthetic peptide, which consists of the N-terminal adrenocorticotropic hormone fragment (4-7) (ACTH4-7) and C-terminal Pro-Gly-Pro peptide. Semax promotes neuron survival in hypoxia, increases selective attention and memory storage. It was shown that this synthetic peptide exerted a number of gene expressions, especially brain derived… (More)