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The diffuse form of systemic sclerosis (SSc) can often lead to a rapidly progressive course with the involvement of the visceral organs which causes a severe prognosis. The 5-years cumulative mortality is between 30 and 60%, depending on the clinic form at the onset. Until now, no drug treatment has been proved to be efficacious against the progression of… (More)
In order to characterize the adrenergic control of pancreatic A cell, the effect on the glucagon secretion of three sympathomimetic substances (epinephrine, isoproterenol, phenylephrine) and two adrenergic blockers (propranolol and phentolamine) have been separately examined by the isolated perfused rat pancreas. The study was performed in basal state and… (More)
The authors describe a case of papillary carcinoma of the thyroid in a young patient with Graves-Basedow disease, diagnosed 10 years ago and now in long-term remission. Remission was achieved after many cycles of methimazole treatment for recurrent hyperthyroid disease. Clinical symptoms, characterized by pain and nodular swelling in the region of the left… (More)
The Authors describe a case of immuno-hemolytic anemia in a 67-year-old woman with hypertension who had been treated irregularly with lisinopril for three months. The hemolytic crisis resolved promptly after withdrawal of lisinopril and did not recur under high-dose methylprednisolone therapy.
To investigate the site and mode of action of progesterone in inducing gonadotropin release, the effects of catecholamine-depleting (methyldopa) or dopamine agonist (bromocriptine) drugs on progesterone positive feedback and the gonadotropin response to a centrally acting noradrenergic drug (clonidine) were evaluated in estrogen-primed postmenopausal women.… (More)
The authors describe a case of hydatid cystic disease presenting as a pulmonary excavation lesion. The peculiarity of this case consisted in the absence of the typical clinical symptoms caused by echinococcal cyst rupture into the bronchial cavity, e.g., hydatid vomica or allergic reaction to parasite antigens. The patient's work history and birthplace (he… (More)
Two groups of receptors, one which develops a stimulating effect (alpha 1), the other an inhibitory effect hae recently been isolated in the alpha adrenergic group. In order to type the B cell adrenergic receptor of the endocrine pancreas, which mediates the inhibitory action exerted by the catecholamines on insulin secretion, the release of this hormone… (More)
The Authors report the persistence of regular menses in a very old woman. Although in the absence of a pulsatile gonadotropin pattern the patient showed estradiol levels typical of the reproductive age.