P A Mirkhamidova

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A radioprotective effect of cow colostrum factor in rats injected subcutaneously in a dose of 1 mg/g body weight 30 min before and for 4 days after whole-body γ-irradiation (8 Gr) is demonstrated. The factor improves survival rate and accelerates postirradiation recovery of nuclear structures and RNase and ATPase activities of the nucleus.
X-irradiation of isolated nuclear envelopes (NE) has revealed their high radiosensitivity, while irradiation of isolated intact nuclei in vitro, in the doses up to 5000 r 18--20 hours after partial hepatectomy, produced no morphological changes in NE. The damaging effect of irradiation on both nuclei and mitochondria (Mt) was revealed only with a decrease(More)
A study was made of the incorporation of 35S-methionine into nuclear matrix proteins of hepatic cells of pregnant rats and their embryos subjected to single gamma-irradiation (60Co, 1 and 2 Gy, 0.0233 Gy/s) on days 3, 13 and 17 of pregnancy and embryogenesis. On day 21 of pregnancy and embryogenesis a decrease in the rate of incorporation of 35S-methionine(More)
A single external gamma-irradiation (1 Gy) of rats on day 35 of their life causes stable structural and functional disturbances in the thyroid gland leading to the development of hypothyrosis at the remote times following irradiation which is demonstrated by the decrease in the concentration of thyroxine in the blood, increase in the thyrotropic function of(More)
Morphological and biochemical investigations of pregnant rats and embryo liver cell nuclei after in vivo irradiation in the doses of 1 and 2 Gr revealed their high radiosensitivity at all stages of gestation and embryonal development. At damaging effect of radiation, we managed to observe sharp accumulation of products of lipid peroxide oxidation and(More)
Rats were irradiated by 8Gr in a doze power of 2.33 R per second. A portion of animals were injected subcutaneously with a cow colostrum polypeptide (CP) in a doze of 1 mg per g of body weight before the irradiation and daily after the irradiation during 4 days. In irradiated rat liver nuclei injected with CP the lipid peroxide oxidation was restored. At(More)
Cytoplasmic as well as nucleoplasmic surfaces of the pore complexes (PC) could be observed using freeze-etching method. The density of PCs per 1 micron2 of nuclear envelope (NE) surface in regenerating liver (9.9) is twice as that in resting liver (5.3). 1 hour after 1200 R X-ray irradiation the pore density in regenerating liver decreases 5.8-fold,(More)
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