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The presence of myositis specific antibodies allows classification of polymyositis into clinically important subsets. Anti Jo-I autoantibodies are associated with 'mechanic's hands' and interstitial lung disease. We report three patients who presented with painful weak muscles, a violaccous rash on the extensor aspect of their hands, elevated muscle(More)
OBJECTIVE To [1] compare the frequency and severity of ultrasound (US) features in people with normal knees (controls), knee pain (KP), asymptomatic radiographic OA (ROA), and symptomatic OA (SROA), [2] examine relationships between US features, pain and radiographic severity, [3] explore the relationship between change in pain and US features over a(More)
OBJECTIVE To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. METHODS A total of 331(More)
This audit suggests that clinical practice in the management of spontaneous pneumothorax differs from guidelines issued by the British Thoracic Society. In particular simple aspiration was attempted in only seven out of 65 patients and clamping of an intercostal chest drain occurred in 12 out of 50 cases. Junior medical staff require more training in(More)
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