P.A. Astolfi

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Theoretical and experimental evidences support the hypothesis that the genomes and the epigenomes may be different in the somatic cells of complex organisms. In the genome, the differences range from single base substitutions to chromosome number; in the epigenome, they entail multiple postsynthetic modifications of the chromatin. Somatic genome variations(More)
The aim of this study was to establish the importance of genetic, biological and environmental factors which may affect sex ratio at birth in dairy cattle. Four main kinds of variations may be considered: heterogeneity between the mothers with respect to the probability of a male birth, variation in this probability according to parity within the progenies;(More)
Simple tandem repeats represent more than 1% of the human genome: occasionally they exhibit intergenerational expansibility and are associated with neuromuscular diseases. In transgenic mice the same sequences elicit similar symptoms, but do not expand. We have searched for di-, tri-, and tetra-repeats in the published DNA sequences of chromosomes 21 and 22(More)
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