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BACKGROUND In rodents, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inactive 11-dehydrocorticosterone (DHC) into active corticosterone. The mRNA and activity of(More)
Platelets play a key role in atherothrombosis, and antiplatelet drugs therefore constitute a cornerstone in the treatment of this disease. One strategy is to target the effects of thromboxane (Tx)A2,(More)