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- Kirsty L. Spalding, Erik Arner, +12 authors Peter Arner
- Nature
- 2008
Obesity is increasing in an epidemic manner in most countries and constitutes a public health problem by enhancing the risk for cardiovascular disease and metabolic disorders such as type 2 diabetes.… (More)
- Erik Arner, Pål O. Westermark, +5 authors Peter Arner
- Diabetes
- 2010
OBJECTIVE
Adipose tissue may contain few large adipocytes (hypertrophy) or many small adipocytes (hyperplasia). We investigated factors of putative importance for adipose tissue morphology.
… (More)
- Paul Florian Thaben, Pål O. Westermark
- Journal of biological rhythms
- 2014
A fundamental problem in research on biological rhythms is that of detecting and assessing the significance of rhythms in large sets of data. Classic methods based on Fourier theory are often… (More)
- Angela Relógio, Pål O. Westermark, Thomas Wallach, Katja Schellenberg, Achim Kramer, Hanspeter Herzel
- PLoS Computational Biology
- 2011
The circadian clock is accountable for the regulation of internal rhythms in most living organisms. It allows the anticipation of environmental changes during the day and a better adaptation of… (More)
- Katja Vanselow, Jens T. Vanselow, +7 authors Achim Kramer
- Genes & development
- 2006
PERIOD (PER) proteins are central components within the mammalian circadian oscillator, and are believed to form a negative feedback complex that inhibits their own transcription at a particular… (More)
- Ute Abraham, Adrián E. Granada, Pål O. Westermark, Markus Heine, Achim Kramer, Hanspeter Herzel
- Molecular systems biology
- 2010
Circadian clocks are endogenous oscillators driving daily rhythms in physiology and behavior. Synchronization of these timers to environmental light-dark cycles ('entrainment') is crucial for an… (More)
- Sarah Lück, Kevin Thurley, Paul Florian Thaben, Pål O. Westermark
- Cell reports
- 2014
The rich mammalian cellular circadian output affects thousands of genes in many cell types and has been the subject of genome-wide transcriptome and proteome studies. The results have been enigmatic… (More)
- James C. W. Locke, Pål O. Westermark, Achim Kramer, Hanspeter Herzel
- BMC Systems Biology
- 2007
Virtually all living organisms have evolved a circadian (~24 hour) clock that controls physiological and behavioural processes with exquisite precision throughout the day/night cycle. The… (More)
- Steven A. Brown, Dieter Kunz, +5 authors Achim Kramer
- Proceedings of the National Academy of Sciences…
- 2008
Human beings exhibit wide variation in their timing of daily behavior. We and others have suggested previously that such differences might arise because of alterations in the period length of the… (More)
- Michael J. Hughes, Katherine C. Abruzzi, +90 authors John B. Hogenesch
- Journal of biological rhythms
- 2017
Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites,… (More)