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  • A J Cook, R E Gilbert, +6 authors D T Dunn
  • 2000
OBJECTIVE To determine the odds ratio and population attributable fraction associated with food and environmental risk factors for acute toxoplasmosis in pregnancy. DESIGN Case-control study. SETTING Six large European cities. PARTICIPANTS Pregnant women with acute infection (cases) detected by seroconversion or positive for anti-Toxoplasma gondii IgM(More)
From 1992 to 1994, a prospective case-control study designed to identify preventable risk factors for Toxoplasma gondii infection in pregnancy was conducted in Norway. Case-patients were identified through a serologic screening program encompassing 37,000 pregnant women and through sporadic antenatal testing for Toxoplasma infection. A total of 63 pregnant(More)
Previous studies indicate reduced risk of type 1 diabetes after intake of vitamin D supplements during pregnancy or early childhood. We aimed to test whether lower maternal serum concentrations of 25-hydroxy-vitamin D (25-OH D) during pregnancy were associated with an increased risk of childhood-onset type 1 diabetes. In this case-control study nested(More)
OBJECTIVE Toxoplasmosis during pregnancy can cause fetal infection, with unpredictable sequelae in later life. We measured the effects of prenatal antibiotic therapy on the fetomaternal transmission of Toxoplasma gondii and on the appearance of sequelae in the congenitally infected child at age 1 year. STUDY DESIGN In a multicenter study we investigated(More)
From 1992 to 1994 a screening program for detection of specific Toxoplasma gondii antibodies involving 35,940 pregnant women was conducted in Norway. For women with serological evidence of primary T. gondii infection, amniocentesis and antiparasitic treatment were offered. The amniotic fluid was examined for T. gondii by PCR and mouse inoculation to detect(More)
A case of diphtheria, which has not been seen in Norway for 30 years, was reported in 1992 in the northern part of the country bordering Russia. An increasing number of cases of diphtheria has been reported in the former USSR, including the northwestern part of Russia. In order to elucidate the potential of an epidemic spread across the Norwegian-Russian(More)
OBJECTIVE Our purpose was to evaluate different methods of diagnosing congenital toxoplasmosis prenatally by amniocentesis and cordocentesis. STUDY DESIGN In a retrospective multicenter study, we investigated consecutive women who had seroconversion for Toxoplasma gondii during pregnancy and who underwent either amniocentesis or cordocentesis or both to(More)
BACKGROUND The aim of this study was to assess the impact of maternal cytomegalovirus (CMV) antibody status in pregnancy on the risk of fetal death and of low birth weight. METHODS The study of fetal death risk was a nested case-control study. Cases were all women within a cohort of 35,940 pregnant women in Norway 1992--94, who experienced fetal death(More)
During one year from June 1992 serum IgG antibodies to Toxoplasma gondii among 35,940 pregnant women were measured in a cross-sectional study conducted in Norway. The overall prevalence was 10.9%. The lowest prevalences were detected in the north (6.7%) and in the inland counties (8.2%). A significantly higher prevalence was detected in the southern(More)
OBJECTIVE To investigate the reliability of the different methods used in Norway and Russia for detection of diphtheria antitoxin. METHODS One hundred and twenty-two sera were selected among Russian serum samples previously collected for seroepidemiologic studies of diphtheria antitoxin. The sera were selected to cover the total antitoxin range and were(More)