Most unmyelinated nociceptive neurons that mediate pain and temperature sensation from the skin bind isolectin B4 (IB4)-lectin and express Ret, the common signaling component of glial cell line-derived neurotrophic factor (GDNF) family. One of these factors, neurturin, is expressed in the epidermis, whereas its GDNF family receptor alpha2 (GFRalpha2) is… (More)
Glial cell line-derived neurotrophic factor family receptor (GFRalpha) 4, the binding receptor for persephin, is coexpressed with the signaling Ret receptor tyrosine kinase predominantly in thyroid calcitonin-producing C cells. We show by in situ hybridization and immunohistochemistry that the functional, glycolipid-anchored form of GFRalpha4 is produced in… (More)
Mammary gland development commences during embryogenesis with the establishment of a species typical number of mammary primordia on each flank of the embryo. It is thought that mammary cell fate can only be induced along the mammary line, a narrow region of the ventro-lateral skin running from the axilla to the groin. Ectodysplasin (Eda) is a tumor necrosis… (More)
Next page: Dry translation from not so dry Northern Karelian dialect: Have I the face to talk to You? I have almost died and tipped over in this company, and it would be lighter to walk if I got more money. Ilikijääkö Teile huastoo? Mie oon melekee kuolta keikahtana tiällä virmassa ja miusta ois keppiimp käyvä, jos sais lissää rahhoo.
Academic dissertation To be presented for public criticism, with the permission of the Faculty of