Most unmyelinated nociceptive neurons that mediate pain and temperature sensation from the skin bind isolectin B4 (IB4)-lectin and express Ret, the common signaling component of glial cell line-derived neurotrophic factor (GDNF) family. One of these factors, neurturin, is expressed in the epidermis, whereas its GDNF family receptor alpha2 (GFRalpha2) is… (More)
Glial cell line-derived neurotrophic factor family receptor (GFRalpha) 4, the binding receptor for persephin, is coexpressed with the signaling Ret receptor tyrosine kinase predominantly in thyroid calcitonin-producing C cells. We show by in situ hybridization and immunohistochemistry that the functional, glycolipid-anchored form of GFRalpha4 is produced in… (More)
Mammary gland development commences during embryogenesis with the establishment of a species typical number of mammary primordia on each flank of the embryo. It is thought that mammary cell fate can only be induced along the mammary line, a narrow region of the ventro-lateral skin running from the axilla to the groin. Ectodysplasin (Eda) is a tumor necrosis… (More)
Academic dissertation To be presented for public criticism, with the permission of the Faculty of
Next page: Dry translation from not so dry Northern Karelian dialect: Have I the face to talk to You? I have almost died and tipped over in this company, and it would be lighter to walk if I got more money. Ilikijääkö Teile huastoo? Mie oon melekee kuolta keikahtana tiällä virmassa ja miusta ois keppiimp käyvä, jos sais lissää rahhoo.