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Erk1/2 activation contributes to mouse ES cell pluripotency. We found a direct role of Erk1/2 in modulating chromatin features required for regulated developmental gene expression. Erk2 binds to specific DNA sequence motifs typically accessed by Jarid2 and PRC2. Negating Erk1/2 activation leads to increased nucleosome occupancy and decreased occupancy of(More)
Many smartphone applications are web based and rely on cookies to maintain the status of a web session. Cookies, however, may lead to security threats since they may contain sensitive information. In addition, an attacker having access to a cookie can easily impersonate the legitimate user. In this paper, we propose and implement a system that securely(More)
Wireless network traces have been widely used to understand human behaviors and provide value-added services. Sanitization based techniques have been shown to be severely lacking in protecting sensitive user information embedded in such traces. In this paper, we take an encryption based approach that provides much stronger protection of user privacy. One(More)
Chromatin immunoprecipitation (ChIP) is a technique used to determine the association of proteins or histone modifications with chromatin regions in living cells or tissues, and is used extensively in the chromatin biology field to study transcriptional and epigenetic mechanisms. Increasing evidence points to an epigenetic coordination of signaling(More)
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