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OBJECTIVE To examine whether metformin is able to reduce insulin resistance in polycystic ovary syndrome (PCOS). DESIGN Single-blind study comprising two successive periods of treatment: 8 weeks of placebo and 10 weeks of metformin (orally, 850 mg twice daily). SETTING Clinic of endocrinology and metabolism of Cerrahpaşa Medical Faculty at Istanbul(More)
This retrospective clinical study was designed to analyze the impact of the initial surgical procedure on the survival of 1000 patients with differentiated thyroid cancer of follicular cell origin who had a thyroid operation and were followed for the 30 years between 1968 and 1998 (median 14 years) in an iodine-deficient region where goiter is endemic.(More)
Familial acromegaly without features of multiple endocrine neoplasie type 1 (MEN 1) is an exceptional clinical entity. We report in this article three cases of acromegaly due to pituitary macroadenomas without any other endocrinopathy in a family. A 31-year-old woman (subject A) and her 34-year-old sister (subject B) with elevated basal rolactin (PRL)(More)
AIM To investigate if obesity which is not accompanied by diabetes and/or hypertension is associated with microalbuminuria in female patients. MATERIALS AND METHODS A total of 77 obese female patients from the Outpatient Clinic of Endocrinology of Istanbul University Cerrahpasa Medical Faculty and 30 age-matched, lean, healthy women were enrolled in the(More)
In this paper we describe a patient with polycythemia vera (PV), who presented with hypercalcemia due to a parathyroid adenoma. In November 1999, the patient was admitted to our hospital with meteorism and constipation. Her physical examination revealed plethora and hepatosplenomegaly. Laboratory data revealed hyperparathyroidism in addition to PV: Rbc 8 x(More)
  • Ozer Açbay
  • Journal of endocrinological investigation
  • 2001
To examine the effect of low-dose losartan, an angiotensin II antagonist, on persistent microalbuminuria in normotensive Type 1 diabetes mellitus, 16 subjects with Type 1 diabetes were randomly assigned to two 2-month treatment periods, with either losartan (25 mg/day) or enalapril (5 mg/day) in a single-blind cross-over design. Urinary albumin excretion(More)
OBJECTIVE To determine the frequency of antithyroid antibodies and the presence of autoimmune thyroiditis among patients with primary Sjögren's syndrome. DESIGN A case-control study. METHODS 53 consecutive patients with primary Sjögren's syndrome, 30 with rheumatoid arthritis, 12 with secondary Sjögren's syndrome associated with rheumatoid arthritis, 17(More)
OBJECTIVE The aim of this study was to determine the accuracy of bilateral cavernous sinus sampling (CSS) in preoperative tumor lateralization (right/left) within the pituitary in patients with Cushing's disease (CD). PATIENTS AND METHODS The study consisted of 26 consecutive patients who had undergone CSS followed by transsphenoidal surgery (TS) for CD(More)
In our clinical experience, postprandialsymptomatic hypoglycemic (PSH) patients with H. pylorigastritis showed a substantial improvement in theirhypoglycemic symptoms after the eradication of H.pylori. Therefore, in this study we have investigatedwhether H. pylori gastritis may contribute to theoccurrence of PSH. For this purpose, we have evaluatedthe(More)