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Ferrocenyl-substituted aziridinylmethanol (Fam-1) was used as a catalyst with zinc for the asymmetric nitroaldol (Henry) reaction. This catalyst worked with a variety of aldehydes (aromatic, aliphatic, alpha,beta-unsaturated, and heteroaromatic) and alpha-ketoesters to give the nitroaldol product in up to 97% yield and 91% ee. The chiral ligand can be… (More)
In the title compound, [Cu(C(16)H(19)BrNO(4))(2)]·2H(2)O, the Cu(II) ion resides on an inversion centre and is coordinated by two O and two N atoms from two enanti-omeric 5-(4-bromo-phen-yl)-4-(tert-but-oxy-carbon-yl)pyrrolidine-2-carboxyl-ate ligands in a distorted square-planar geometry. The relative stereochemistry of the three stereogenic C atoms in… (More)
Ferrocenyl-substituted aziridinylmethanol (Fam-1) has been used as a chiral catalyst with titanium for enantioselective alkynylation of aromatic, heteroaromatic, aliphatic, and alpha,beta-unsaturated aldehydes to give the corresponding propargylic alcohols in up to 96% yield and 96% ee. The ligand can be prepared easily and recycled.
[reaction: see text] A new chiral aziridino alcohol ligand for zinc(II)-catalyzed azomethine ylide cycloadditions is described. In the presence of this catalyst, N-arylidene glycine methyl esters react with a variety of dipolarophiles to give substituted pyrrolidines in very good to excellent chemical yields and up to 95% ee. The absolute sense of… (More)