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Fragment-based lead generation has led to the discovery of a novel series of cyclic amidine-based inhibitors of beta-secretase (BACE-1). Initial fragment hits with an isocytosine core having(More)
by a simple penicillin disc test is recommended. Any strain growing up to, or producing only a small zone of inhibition round a 1 |ig disc should be tested for 3-lactamase production by the(More)
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