Owen C Grush

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Circulating erythropoietic precursors in normal men and patients with hemoglobinopathies were characterized in culture. Blood mononuclear cells harvested with a modification of the Ficoll-Isopaque technique were cultured in methylcellulose for 14 days. The majority of erythropoietic colonies consisted of several subcolonies assuming the morphology of(More)
Significant bleeding associated with inadvertent heparin overdosage may occur in children with cancer and indwelling central venous catheters. The etiology of such bleeding, as described in a child with Wilms' tumor, may not be immediately apparent. It is imperative that the proper techniques for maintenance and anticoagulation of the catheter be(More)
A 14-year-old girl with chronic idiopathic thrombocytopenic purpura (ITP) presented in relapse with a platelet count of 1,000/microL and a high-level serum antiplatelet IgG antibody. She previously had been unresponsive to courses of therapy with steroids, vincristine, and splenectomy. When treatment with danazol and purified immunoglobulins was(More)
Bone marrows from 21 children with acute lymphoblastic leukemia in complete remission (CR) and off therapy for 14 months to 10 years were examined by flow cytometry with a panel of monoclonal antibodies. Significant percentages of cALLA+ cells of low fluorescence intensity were present up to 9 years after CR. These results emphasize the need to interpret(More)
Evidence of growth failure at diagnosis and of acute or chronic malnutrition during management was sought in 43 children who had solid tumors, 14 with Wilms' tumor, 17 with sarcoma and 12 with neuroblastoma. Growth failure at diagnosis was identified from height and weight percentiles, acute malnutrition from weight/height ratio, and chronic malnutrition(More)