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Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium.
In vitro models of normal mammary epithelium have correlated increased extracellular matrix (ECM) stiffness with malignant phenotypes. However, the role of increased stiffness in this transformationExpand
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Mechanics and contraction dynamics of single platelets and implications for clot stiffening.
Platelets interact with fibrin polymers to form blood clots at sites of vascular injury. Bulk studies have shown clots to be active materials, with platelet contraction driving the retraction andExpand
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Hydrogels with tunable stress relaxation regulate stem cell fate and activity
Natural extracellular matrices (ECMs) are viscoelastic and exhibit stress relaxation. However, hydrogels used as synthetic ECMs for three-dimensional (3D) culture are typically elastic. Here, weExpand
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Substrate stress relaxation regulates cell spreading.
Studies of cellular mechanotransduction have converged upon the idea that cells sense extracellular matrix (ECM) elasticity by gauging resistance to the traction forces they exert on the ECM.Expand
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Matrix Elasticity of Void-Forming Hydrogels Controls Transplanted Stem Cell-Mediated Bone Formation
The effectiveness of stem-cell therapies has been hampered by cell death and limited control over fate1. These problems can be partially circumvented by using macroporous biomaterials that improveExpand
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Actin filament curvature biases branching direction
Mechanical cues affect many important biological processes in metazoan cells, such as migration, proliferation, and differentiation. Such cues are thought to be detected by specialized mechanosensingExpand
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Mitotic cells generate protrusive extracellular forces to divide in three-dimensional microenvironments
During mitosis, or cell division, mammalian cells undergo extensive morphological changes, including elongation along the mitotic axis, which is perpendicular to the plane that bisects the twoExpand
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YAP-independent mechanotransduction drives breast cancer progression
Increased tissue stiffness is a driver of breast cancer progression. The transcriptional regulator YAP is considered a universal mechanotransducer, based largely on 2D culture studies. However, theExpand
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Strain-enhanced stress relaxation impacts nonlinear elasticity in collagen gels
Significance The extracellular matrix is a complex assembly of structural proteins that provides physical support and biochemical signaling to cells within our tissues. One of the key structuralExpand
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Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces.
Contractile cells can reorganize fibrous extracellular matrices and form dense tracts of fibers between neighboring cells. These tracts guide the development of tubular tissue structures and provideExpand
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