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Some anti-inflammatory tests based on the carrageenan induced oedema rat paw method have been carried out with a freeze-dried aqueous extract and an etheropetrolic extract of Cailcedrat (Khaya senegalensis) barks. Then, a preliminary chemical study to find a relation structure/activity has been done from the etheropetrolic extract, by using various(More)
In a former study, it was proved that the alcoholic solution of hydro-alcoholic extract of Khaya senegalensis barks had an anti-inflammatory activity on animals after a local application. In this work, ointments made from the same extract and three different excipients (vaseline, lanoline and shea butter (crude and refined)) have been prepared and tested by(More)
Due to colonization (1895-1960) Mali has been submitted, on the legislative and regulation plan to a corpus of numerous and scattered texts relative to pharmacy. It is essentially the Law AN XI of 21 Germinal or the 11 April 1803 Law; the content of Book V of the Public Health Code relative to pharmacy practice, of which some disposals have been extended to(More)
An hydroxypropylmethyl cellulose phthalate (HP55) pseudolatex was prepared by a nanoprecipitation method. This allows nanoparticles formation when a solution of the polymer in an organic solvent (phase S1 or organic phase) is introduced in a precipitant medium (phase S2 or aqueous phase) which consists of water containing surfactant. A modification of the(More)
The aim of this work was to compare the anti-inflammatory activity of the total extract of Khaya senegalensis Barks and its different fractions for optimizing the active ingredients which be used in the ointment formulation. For that, a fractionation was performed followed by anti-inflammatory tests based on the method of the croton oil induced oedema.(More)
The aim of this work was to prepare a pharmaceutical using the aqueous extract of bakis roots and to check if the choleretic activity of this latter was maintained in cholestatic rats. So, a sirup was prepared and tested. The obtained results had shown that the aqueous extract maintained its choleretic activity. Indeed, when it was used at a dose of about(More)
PURPOSE Diabetes Type I is a chronic disease requiring insulin repeated injections by parenteral during a lifetime. This method of administration as well as traumatic can be a problem for adherence of patients to treatment. In order to overcome these difficulties, we considered the development of therapeutic transdermal drug delivery (TTDD) of insulin. (More)
A shea butter ointment containing 3% aureomycin (clortetracyclin hydrocloride) was prepared and some of its macroscopic and microscopic characteristics were evaluated. Then, the release of the active ingredient was compared by UV spectrophotometry with those obtained when excipients such as petroleum jelly and lanoline were used. Results had shown that the(More)
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