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Agouti-related peptide (AgRP) neurons of the hypothalamus play a key role in regulating food intake and body weight, by releasing three different orexigenic molecules: AgRP; GABA; and neuropeptide Y. AgRP neurons express various G protein-coupled receptors (GPCRs) with different coupling properties, including Gs-linked GPCRs. At present, the potential role(More)
There is increasing awareness of the link between impaired circadian clocks and multiple metabolic diseases. However, the impairment of the circadian clock by type 2 diabetes has not been fully elucidated. To understand whether and how the function of circadian clock is impaired under the diabetic condition, we examined not only the expression of circadian(More)
To investigate the effects of a short-term feeding stimulus on the expression of circadian genes in peripheral tissues, we examined the effects of a 30-min feeding stimulus on the rapid responses and circadian phases of five clock genes (Bmal1, Cry1, Per1, Per2 and Per3) and a clock-controlled gene (Dbp) in the heart and kidney of rats. A 30 min feeding(More)
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