Otto Staindl

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A report is given about the clinical experiences, made with a biological adhesive-system, consisting in thrombin, native human fibrinogen and clotting factor XIII. We used this adhesive-system in 28 cases of free skin-grafts, without any other kinds of skin-fixation. The highly adhesive properties, the good tissue compatibility recommend this system for(More)
53 Lewis lung carcinomas implanted subcutaneously into C57BL/6-mice were examined. The animals were killed at various stages of tumor growth (TG) and prepared for histology and for scanning electron microscopy (critical-point-dried tissue; vascular corrosion casts). Prior to casting animals were rinsed using different perfusion pressures. Casting was done(More)
In vielen chirurgischen Fächern gewinnt die Verwendung hochkonzentrierten humanen Fibrinogens, welches mit Thrombin zur Fällung gebracht wird, als Gewebekleber zunehmend an Bedeutung. Eine Reihe von klinischen und experimentellen Berichten liegt bereits vor. In unseren Untersuchungen haben wir uns die Frage gestellt: Wie verhält sich der Gewebekleber nach(More)
The present paper reports the central role of fibrin (and specifically its pre-stage, fibrinogen), thrombin and coagulation factor XIII in wound healing and scar formation. The significance of these three factors has led to the development of a tissue adhesion system on a physiological basis, which can be applied in widely varying areas of surgery. The(More)
  • Otto Staindl
  • The Annals of otology, rhinology, and laryngology
  • 1979
This paper summarizes a tissue adhesive system consisting of highly concentrated human fibrinogen and thrombin. The addition of blood-clotting factor XIII stabilizes the adhesive system against fibrinolysis. Although the adhesion system cannot and should not replace surgical suture, it provides valuable assistance in tissue synthesis and in local(More)
Three keloids harvested during surgery were prepared for histology and scanning electron microscopy (SEM) of vascular corrosion casts. One well-filled keloid (12 cm x 7 cm) was examined by SEM. This specimen revealed a conspicuous increase in subepidermal venous vessels as well as prominent luminal bulging of the endothelial lining in arterial and venous(More)
Three types of saddle-nose deformities can be distinguished: 1. the pseudo-saddle nose, 2. the slight saddle nose, 3. the extensive saddle nose. The pseudo-saddle nose may show a depression of the cartilaginous dorsum due to a hump, frequently accompanied by widening of the bony bridge and a prominent nasal tip. Satisfactory correction of this type of(More)
Light microscopy of hematoxylin-eosin stained tissue sections and scanning electron microscopy (SEM) of vascular corrosion casts were used to study the blood vascular system of human basal cell tumors. Concerning the gross angioarchitecture there is a very close correlation between the histological appearance and the findings obtained from vascular(More)
The risk of complications of auricular correction is underestimated. There is around a 5% risk of early complications (haematoma, infection, fistulae caused by stitches and granulomae, allergic reactions, pressure ulcers, feelings of pain and asymmetry in side comparison) and a 20% risk of late complications (recurrences, telehone ear, excessive edge(More)
Various conservative and surgical procedures are available for the management of aggressive hemangiomas in infancy and childhood. One of them is magnesium seeding, a treatment modality developed more than 90 years ago but neglected for a long time. The technique consists of implanting 0.5- to 1-mm-thick wires of 99.8% pure magnesium into the tumor mass.(More)