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INTRODUCTION Cerebral Oximetry is an optical technique that allows for noninvasive and continuous monitoring of brain oxygenation by determining tissue oxygen saturation (SctO2). In conjunction with pulse oximetry, cerebral oximetry offers a promising method to estimate cerebral venous oxygen saturation (SvO2). OBJECTIVE The aim of this study was to(More)
BACKGROUND Nitrogen dioxide (NO2) is a toxic by-product of inhalation therapy with nitric oxide (NO). The rate of NO2 formation during NO therapy is controversial. METHODS The formation of NO2 was studied under dynamic flows emulating a base case NO ventilator mixture containing 80 ppm NO in a 90% oxygen matrix. The difficulty in measuring NO2(More)
The differential arrangement of two pneumotachographs in a gas blow-by system, upstream and downstream from the patient connection port, permits accurate measurement of the tracheal air flow without introduction of flowmeter dead-space. The method does not require but will accept a constant background gas flow rate and permits humidification and easy(More)
OBJECTIVE A state-of-the-art centrifugal pump combined with hollow-fiber oxygenator for extracorporeal membrane oxygenation has potential advantages such as smaller priming volumes and decreased potential to cause tubing rupture as compared with the traditional roller head/silicone membrane systems. Adoption of these state-of-the-art systems has been slow(More)
OBJECTIVES To determine whether the new double-lumen catheter made by OriGen Biomedical (Austin, TX) for venovenous (VV) extracorporeal membrane oxygenation (ECMO) would reduce recirculation and improve oxygenation during VV ECMO when compared with the Kendall double-lumen catheter (Kendall Healthcare Products, Mansfield, MA). DESIGN Prospective(More)
The differential diagnosis of congenital heart disease from persistent fetal circulation is clinically difficult and cardiac catheterization is often needed. The development of a safe, new technique for use of the rebreathing method has allowed the determination of effective pulmonary blood flow, lung tissue volume, lung diffusion capacity and functional(More)
UNLABELLED Venovenous extracorporeal membrane oxygenation (VV ECMO) using double lumen catheters is an alternative to venoarterial (VA) ECMO and allows for total blood flow using the patient's cardiac output in comparison to partial blood flow provided during VA ECMO. OBJECTIVE To compare the effects of VV versus VA ECMO on renal blood flow. DESIGN(More)
The CAS neonatal NIRS system determines absolute regional brain tissue oxygen saturation (SnO2) and brain true venous oxygen saturation (SnvO2) non-invasively. Since NIRS-interrogated tissue contains both arterial and venous blood from arterioles, venules, and capillaries, SnO2 is a mixed oxygen saturation parameter, having values between arterial oxygen(More)
OBJECTIVE To compare intratracheal pulmonary ventilation (ITPV) with conventional ventilation in a rabbit model of surfactant deficiency. DESIGN A prospective randomized animal study. SETTING The Children's National Medical Center Research Animal Facility in Washington, DC. SUBJECTS Adult male New Zealand white rabbits (n = 20), weighing 1.4-4.2 kg.(More)
BACKGROUND AND AIMS In nomothetic research exercise addiction is studied on the basis of symptoms which are most often linked to exercise volume. However, other factors may also affect individuals' susceptibility to the disorder. The aim of this research was to examine the influence of gender, social context (team or individual sport), and level of athletic(More)