Learn More
PURPOSE To evaluate the efficacy and effect of tacrolimus ointment on conjunctival cytology in patients with atopic blepharoconjunctivitis or keratoconjunctivitis. METHODS Ten patients with severe atopic blepharoconjunctivitis treated with 0.03% tacrolimus ointment once daily as an intermittent treatment were analysed retrospectively. The main outcome(More)
Allergic diseases have greatly increased in industrialized countries. About 30% of people suffer from allergic symptoms and 40%-80% of them have symptoms in the eyes. Atopic conjunctivitis can be divided into seasonal allergic conjunctivitis (SAC) and perennial allergic conjunctivitis (PAC). The treatment of SAC is simple; antihistamines, anti-inflammatory(More)
To determine the concentration of group IIA phospholipase A2 (GIIAPLA2) in tears of patients with atopic blepharoconjunctivitis (ABC), and to compare it with the GIIAPLA2 concentration of tears in age-matched healthy controls. The diagnosis of ABC was confirmed with a positive skin prick test and the presence of atopic dermatitis in lids. Conjunctival brush(More)
  • O Kari
  • Acta ophthalmologica
  • 1988
Tarsal conjunctival scrapings of the lower and upper eyelids of 21 atopic, pollen allergic patients with conjunctivitis were examined three times; during a symptom-free period, during a challenge test and during the pollen season. Eosinophils were also counted from the conjunctival fluid of 17 patients, but only of 12 patients during the challenge. The(More)
Tear histamine was measured in 14 patients with allergic conjunctivitis during a challenge test performed at a symptom-free point in time. The allergen challenge caused a rapid increase in the amount of tear histamine in only two-thirds of the patients, but there was a clinical reaction in all. The increase in the tear histamine content occurred in both the(More)
Forty-five patients with presumed acute bacterial conjunctivitis were treated in an investigator-masked randomized multicenter study with either lomefloxacin 0.3% or fucidic acid 1% eye drops twice daily. Clinical signs and symptoms were rated by slit-lamp examination and conjunctival swab cultures were performed to evaluate clinical and microbiological(More)
BACKGROUND Alternaria alternata and Cladosporium herbarum are common fungi in outdoor environments, but their clinical significance has not been elucidated in Finland. OBJECTIVE To evaluate the prevalence of IgE-mediated allergy and clinical outcomes caused by sensitization to fungal allergens in patients with suspected allergy. METHODS Skin prick tests(More)
PURPOSE Matrix metalloproteinase 8 (MMP-8) is an effective collagenolytic enzyme that is associated with many ocular inflammatory diseases, such as uveitis, keratitis, and ocular rosacea. We studied the tear fluid concentration and activation of MMP-8 in atopic blepharoconjunctivitis (ABC) and the presence of the enzyme in conjunctival inflammatory cells in(More)
Ocular rosacea (OcR) is a chronic inflammatory disease especially affecting lid margins. Previous studies have shown that it is accompanied by increased levels and activation of tear fluid gelatinases. Matrix metalloproteinase 8 (MMP-8; collagenase 2) levels and activation are commonly elevated in many inflammatory conditions. Therefore we studied here(More)